Methyltrienolone is the most powerful oral steroid ever produced. This drug is a close relative of trenbolone and differs only in 17-alpha alkylation. This modification makes it significantly more powerful than trenbolone. It is 120-300 times more powerful than methyltestosterone. This is the most powerful steroid available on the market, doses of 0.5-1mg are already enough for a powerful anabolic effect. Its activity is accompanied by strong toxicity, and this is what limits its use in laboratory conditions.
Estrogenic side effects:
Dimethyltrienolone does not aromatize and has no estrogenic activity. Dimethyltrienolone has an affinity for progesterone receptors. This can cause progesterone side effects such as testosterone production to stop and body fat to increase. Progestins also increase the stimulatory effect of estrogen on the growth of breast tissue. There is such a strong synergy that gynecomastia can be caused by progestins alone, without increasing estrogen levels. The use of anti-estrogens may alleviate gynecomastia caused by progestogen AAS.
Androgenic side effects:
Dimethyltrienolone is classified as an anabolic, but androgenic side effects are very possible. It can be increased oily skin, acne, hair growth on the body and face. Anabolic steroids can worsen male pattern hair loss. Women additionally need to be aware of the potential virilizing effects of AAS. This may include a deepening of the voice, irregular periods, changes in skin texture, facial hair growth, and enlargement of the clitoris. Dimethyltrienolone does not react with 5a-reductase and its androgenicity cannot be altered by concomitant use of finasteride or dutasteride.
Side effects (hepatotoxicity):
Dimethyltrienolone is a c17-alpha alkylated drug. This change protects the drug from deactivation by the liver, allowing a greater percentage of the drug to enter the bloodstream after oral ingestion. Alkylated AAS can be hepatotoxic. Long-term use or high doses may cause liver damage. In rare cases, life-threatening dysfunction may develop. It is advisable to visit a doctor periodically on the course to monitor liver function. Alkylated AAS intake is usually limited to 6-8 weeks to avoid increased liver stress. Dimethyltrienolone is a very potent oral steroid and has a high level of resistance to hepatic metabolism. This makes it very toxic to the liver. It can be advised to use supplements that cleanse the liver, such as Liver Stabil, Liv-52 and Essentiale Forte, on the course.
Side effects (cardiovascular system):
AAS can have a harmful effect on blood cholesterol. This may be a decrease in the level of “good” HDL, a shift in the balance towards the risk of atherosclerosis. The relative effect of AAS on lipids depends on dose, route of administration, type of steroid, and level of resistance to hepatic metabolism. Dimethyltrienolone has a stronger negative effect on hepatic cholesterol management due to its non-aromatizing structure and route of administration. AAS can have a negative effect on blood pressure and triglycerides, reduce relaxation of the vascular endothelium, provoke ventricular hypertrophy of the heart, which potentially increases the risk of cardiovascular disease and heart attack. To reduce the burden on the cardiovascular system, it is recommended to minimize the intake of saturated fats, cholesterol and simple carbohydrates during the course of AAS. The use of supplements such as fish oil, lipid stabilizer or similar products is recommended.
Testosterone suppression:
All AAS at doses required for muscle building suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone will return to normal levels within 1-4 months after the cycle. Note that long-term hypogonadotropic hypogonadism may develop into secondary hypogonadism and require medical attention.